Genetic Studies of Acute Tolerance, Rapid Tolerance, and Drinking in the Dark in the LXS Recombinant Inbred Strains

We hypothesized that rapid tolerance (1-day tolerance) for the duration of the loss of righting reflex (“sleep time” [ST]) was mediated by an increase in acute functional tolerance (AFT). We also hypothesized that increased AFT would correspond to increased drinking. These questions were addressed using the LXS recombinant inbred mouse strain panel.



Mice were given a pretreatment dose of