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Alcohol intake, wine consumption and the development of depression: the PREDIMED study









Alcoholic beverages are widely consumed. Depression, the most prevalent mental disorder worldwide, has been related to alcohol intake. We aimed to prospectively assess the association between alcohol intake and incident depression using repeated measurements of alcohol intake.



We followed-up 5,505 high-risk men and women (55 to 80 y) of the PREDIMED Trial
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What is the purpose of BC’s liquor laws in 2013?




Almost 100 years ago Canadian provinces other than Québec voted for the total prohibition of alcohol. In BC this occurred in 1917 following a referendum but was soon repealed in 1921, overwhelmed by a tide of organized crime, official corruption and political scandal. Prohibition was imposed on the aboriginal people of Canada for over a century ending only in 1962.

Key elements of our present
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An Examination of the Social Determinants of Health as Factors Related to Health, Healing and Prevention of Fetal Alcohol Spectrum Disorder in a Northern Context – The Brightening Our Home Fires Project, Northwest Territories, Canada






The Brightening Our Home Fires (BOHF) project was conceptualized as an exploratory project to examine the issue of the prevention of foetal alcohol spectrum disorder (FASD) from a women’s health perspective in the Northwest Territories (NT). While dominant discourse suggests that FASD is preventable by abstention from alcohol during pregnancy, a broader perspective would indicate that
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Oxidation of ethanol in the rat brain and effects associated with chronic ethanol exposure




It has been reported that chronic and acute alcohol exposure decreases cerebral glucose metabolism and increases acetate oxidation. However, it remains unknown how much ethanol the living brain can oxidize directly and whether such a process would be affected by alcohol exposure. The questions have implications for reward, oxidative damage, and long-term adaptation to drinking.One group of
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Trends in the prevalence of multiple substance use in adolescents in England, 1998–2009






This study examines demographic risk factors and trends from 1998 to 2009 for concurrent multiple substance use in adolescence in England.




We used data from the ‘Smoking, Drinking and Drug Use among Young People in England’ survey, a nationally representative annual survey of 11–15 year olds. Measures of smoking, drinking and illicit drug use frequency and weekly alcohol consumption
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The effects of acute alcohol administration on the human brain: Insights from neuroimaging





Over the last quarter century, researchers have peered into the living human brain to develop and refine mechanistic accounts of alcohol-induced behavior, as well as neurobiological mechanisms for development and maintenance of addiction. These in vivo neuroimaging studies generally show that acute alcohol administration affects brain structures implicated in motivation and behavior control,
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Multiple fruit-flavored alcoholic drinks in a can (MFAC): an overlooked class of potentially harmful alcohol products.









This article examines an overlooked class of alcohol products, described herein as multiple fruit-flavored alcoholic drinks in a can (MFAC). The article describes how characteristics of these products likely contribute to hazardous alcohol consumption among youth.

Government regulation of these products may be needed to protect adolescent and young adult populations.

National
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Love and faith





The field of addiction treatment was flawed in 1973, but not nearly as flawed as some would have you believe.



The following is from Marty Mann in 1973 and I could not do a better job of summarizing Dawn Farm’s approach

Para-professionals working in the field of alcoholism are overwhelmingly recovered alcoholics. Most of them credit their recovery to AA, some to the facility where they are
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Reduction of excessive alcohol drinking by a novel GABAB receptor positive allosteric modulator ADX71441 in mice







A promising pharmacotherapy for alcohol use disorders has been positive allosteric modulators (PAMs) of the γ-aminobutyric acid receptor B (GABAB R) since GABAB R PAMs reduce ethanol drinking and self-administration in rodents.


The current studies investigated a novel, selective GABAB R PAM, ADX71441, in comparison to naltrexone in a protocol of ethanol binge-like drinking,
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A retrospective study of gender differences in depressive symptoms and risk of relapse in patients with alcohol dependence



The aim of this study was to investigate potential gender differences in situations associated with heavy alcohol drinking.



Data from 395 alcohol dependent patients participating in the Mayo Clinic Intensive Addiction Program were evaluated. Each participant completed the inventory of drug taking situations (IDTS), Penn alcohol craving scale (PACS), patient health questionnaire (PHQ-9), and
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Alcoholics anonymous and twelve-step recovery: A model based on social and cognitive neuroscience





In the course of achieving abstinence from alcohol, longstanding members of Alcoholics Anonymous (AA) typically experience a change in their addiction-related attitudes and behaviors. These changes are reflective of physiologically grounded mechanisms which can be investigated within the disciplines of social and cognitive neuroscience.



This article is designed to examine recent findings
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Alcohol Intake Between Menarche and First Pregnancy: A Prospective Study of Breast Cancer Risk



Adult alcohol consumption during the previous year is related to breast cancer risk. Breast tissue is particularly susceptible to carcinogens between menarche and first-term pregnancy. No study has characterized the contribution of alcohol consumption during this interval to risks of proliferative benign breast disease (BBD) and breast cancer.
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Drinking and Swimming: Investigating Young Australian Males' Intentions to Engage in Recreational Swimming While Under the Influence of Alcohol.



Drowning, a largely preventable problem, continues to be a serious issue worldwide, with young men particularly at risk. Alcohol and drugs are often present among young males and, particularly for males aged 18–34 years, alcohol is considered to be a significant risk factor for drowning.

The current study aimed to understand the motivations guiding the intentions of young Australian men to
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Validating the ability of a single-item assessing drunkenness to detect hazardous drinking.











To simplify the screening process to identify problem drinking, researchers have developed single-item, quantity-based instruments. Quantity-based items, however, suffer from several limitations.



Determine whether a non-quantity-based single item assessing drunkenness would be able to identify those who exhibited signs of hazardous alcohol use, as determined by Alcohol Use
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The impact of twelve-step program familiarity and its in-session discussion on counselor credibility.







The therapeutic relationship is an important factor in substance abuse treatment. Because Twelve-Step Program (TSP) concepts and principles are often incorporated into substance abuse treatment, we investigated whether counselor familiarity and time spent on TSPs impact counselor credibility.



A sample of 180 clients receiving residential treatment in the capital region of a
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Global Actions: Commitments to Reduce Harmful Drinking. August 28, 2013








Global Actions in Focus

Drink Driving events in Mexico



Throughout the month of August 2013, the Global Actions Drink Drive Initiative in Mexico has hosted several events to promote the campaign, “Toward Zero Deaths for Drinking and Driving in Puebla.” On August 5 through 9, Global Actions launched a pilot program to present drink driving awareness training to approximately 1,000
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MRC, ESRC and Alcohol Research UK Call for research linking harms caused by alcohol to drinking behaviours





The MRC, ESRC and Alcohol Research UK wish to continue making key
contributions to this field, in this case through providing authoritative
evidence on the link between the specific harms caused directly by a distinct
pattern, level and duration of alcohol drinking at key stages in the
life-course. The hypothesis is that establishing such links will provide
breakthroughs in this field
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Alcohol and other drug treatment services in Australia 2011-12






Almost 700 agencies provided over 150,000 treatment episodes for alcohol and other drug issues in Australia in 2011-12. Most of the closed episodes provided in 2011-12 were for clients receiving treatment for their own drug use, and these clients tended to be male and in their 20s and 30s. Alcohol was the most common principal drug of concern, accounting for almost half of these closed
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The role of an Aboriginal women's group in meeting the high needs of clients attending outpatient alcohol and other drug treatment








Support groups are typically offered as part of specialist alcohol or other drug treatment. However, their usefulness with Indigenous Australians has not been examined. This paper provides a profile of Aboriginal women attending an inner city outpatient alcohol and other drug treatment service, insight into how effective women and staff perceive the support group to be at meeting their
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Mindfulness-Based Relapse Prevention with Racial and Ethnic Minority Women





Racial and ethnic disparities in the treatment of addiction have been acknowledged for several years, yet little is known about which empirically supported treatments for substance use disorders are more or less effective in treating racial and ethnic minority clients.

The current study was a secondary analysis of a randomized clinical trial of two evidence-based treatments,
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Personality, cognition and hazardous drinking: Further support for the 2-Component Approach to Reinforcing Substances Model







Personality and cognitive processes are both related to alcohol use and misuse. A recent model of hazardous drinking referred, the 2-CARS model, postulates two major pathways to hazardous drinking. One pathway primarily involves the association between Reward Drive and Positive Outcome Expectancies, the second involves the association between Rash Impulsiveness and Drinking Refusal
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Alcohol Consumption, Heavy Drinking, and Mortality: Rethinking the J-Shaped Curve






High average daily consumption of alcohol has been associated with elevated mortality risk, but more moderate consumption, relative to abstinence, has been associated with reduced mortality risk. However, average daily consumption can be complicated to assess, limiting its usefulness in both research and clinical practice. There are also concerns that average consumption fails to capture the
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Intra-VTA Deltorphin, But Not DPDPE, Induces Place Preference in Ethanol-Drinking Rats: Distinct DOR-1 and DOR-2 Mechanisms Control Ethanol Consumption and Reward

















While there is a growing body of evidence that the delta opioid receptor (DOR) modulates ethanol (EtOH) consumption, development of DOR-based medications is limited in part because there are 2 pharmacologically distinct DOR subtypes (DOR-1 and DOR-2) that can have opposing actions on behavior.






We studied the behavioral influence of the DOR-1-selective agonist [D-Pen2,
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Using Autopsy Brain Tissue to Study Alcohol-Related Brain Damage in the Genomic Age





The New South Wales Tissue Resource Centre at the University of Sydney, Australia, is one of the few human brain banks dedicated to the study of the effects of chronic alcoholism. The bank was affiliated in 1994 as a member of the National Network of Brain Banks and also focuses on schizophrenia and healthy control tissue.

Alcohol abuse is a major problem worldwide, manifesting in such
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The persistence of adolescent binge drinking into adulthood: findings from a 15-year prospective cohort study






To examine the prevalence of binge drinking in adolescence and its persistence into adulthood in an Australian cohort.


15-year prospective cohort study.



Victoria, Australia.



1943 adolescents were recruited from secondary schools at age 14–15 years.


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Stress–response pathways are altered in the hippocampus of chronic alcoholics

The chronic high-level alcohol consumption seen in alcoholism leads to dramatic effects on the hippocampus, including decreased white matter, loss of oligodendrocytes and other glial cells, and inhibition of neurogenesis.

Examining gene expression in post mortem hippocampal tissue from 20 alcoholics and 19 controls allowed us to detect differentially expressed genes that may play a role in the
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High Variability in the Exposure of Baclofen in Alcohol-Dependent Patients







Baclofen is a GABA-B receptor agonist used in the treatment of spasticity. Recently, baclofen is used out of its label to decrease craving of alcoholic patients. Its optimal use in these patients requires further pharmacokinetic information. The objective of this study was to characterize the pharmacokinetics of baclofen in alcohol-dependent patients. Randomized clinical trials are ongoing
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Reduction in Central H2O2 Levels Prevents Voluntary Ethanol Intake in Mice: A Role for the Brain Catalase-H2O2 System in Alcohol Binge Drinking




Hydrogen peroxide (H2O2) is the cosubstrate used by the enzyme catalase to form Compound I (the catalase-H2O2 system), which is the major pathway for the conversion of ethanol (EtOH) into acetaldehyde in the brain. This centrally formed acetaldehyde has been shown to be involved in some of the psychopharmacological effects induced by EtOH in rodents, including voluntary alcohol intake. It has
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The Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) in the Assessment of Alcohol Use Disorders Among Acute Injury Patients







The Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) is a brief alcohol screening test and a candidate for inclusion in recommended screening and brief intervention protocols for acute injury patients. The objective of the current study was to examine the performance of the AUDIT-C to risk stratify injury patients with regard to their probability of having an alcohol use
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Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Adolescent Versus Adult Mice






Alcohol use occurs across the life span beginning in adolescence and continuing through adulthood. Ethanol (EtOH)-induced pathology varies with age and includes changes in neurogenesis, neurodegeneration, and glial cell activation. EtOH-induced changes in glial activation and immune activity are believed to contribute to EtOH-induced neuropathology. Recent studies indicate an emerging role
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Infant Emotional Withdrawal: A Precursor of Affective and Cognitive Disturbance in Fetal Alcohol Spectrum Disorders






Our aim was to test the hypothesis that emotional withdrawal is an early indicator of affective disorder in infants heavily exposed prenatally to alcohol, which is independent of alcohol-related effects on mother–infant interaction and temperament and discriminated between children later diagnosed with fetal alcohol syndrome (FAS) and partial FAS (PFAS) and predicted cognitive and affective
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Repeated Diagnoses of Lifetime Alcohol Use Disorders in a Prospective Study: Insights into the Extent and Nature of the Reliability and Validity Problem





Prior research indicates that assessments of lifetime alcohol use disorders (AUDs) show low sensitivity and are unreliable when assessed by a single, retrospective interview. This study sought to replicate and extend previous research by calculating the lifetime prevalence rate of AUDs using both single retrospective assessments of lifetime diagnosis and repeated assessments of both lifetime
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The Relationship Between Excessive Alcohol Consumption and Alcohol Use Disorders According to DSM-IV and DSM-5





Although it seems intuitive that alcohol use disorders (AUDs) include excessive alcohol consumption (EAC), this notion is not well established. This study investigates to which degree EAC (defined as >14/21 drinks weekly for women/men and at least three 5+ drinking days per week) and AUD overlap and whether problematic alcohol use groups (EAC-only, AUD-only, and EAC + AUD) differ from each
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Epigenetics—New Frontier for Alcohol Research








The term “epigenetics” is rapidly becoming one of the more important watchwords in the field of alcohol research. Put simply, epigenetics is the study of changes in gene function that occur without a change in the body’s genetic code. Instead epigenetic “markers” turn genes “on” and “off.” By acting on these epigenetic markers, environmental factors such as diet, stress, and prenatal
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Alcohol attenuates amygdala–frontal connectivity during processing social signals in heavy social drinkers








Convergent evidence shows that alcohol exerts its effects on social behavior via modulation of amygdala reactivity to affective stimuli. Given that affective processing involves dynamic interactions between the amygdala and the prefrontal cortex (PFC), alcohol’s effects are likely to extend beyond regional changes in brain activity to changes that manifest on a broader functional circuit
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Acute alcohol effects on subtypes of impulsivity and the role of alcohol-outcome expectancies










It is well established that alcohol acutely impairs the ability to inhibit a pre

-potent response (motor impulsivity), but its effects on cognitive impulsivity, including temporal (delayed gratification) and reflection (decision making) impulsivity, are not clear. An important factor contributing to the effects of alcohol is cognitive expectancies of alcohol-related outcomes.



The
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Alcohol News - 34/2013








YLE.fi (Finland) - Ministry memo: Tighter
controls, higher taxes for alcohol





Finland's Ministry of Social Affairs and Health
issued a memorandum on Wednesday intended as the basis for revisions to alcohol
legislation. Among the measures proposed are shorter sales hours, higher taxes
on alcohol, and possibly lowering the permitted alcohol content of beers, ciders
and pre-mixed
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Alcohol consumption enhances vection






We assessed changes in forward vection following alcohol consumption, and found
that alcohol consumption enhanced vection. This result indicates that alcohol
can affect psychophysical processes responsible for self-motion perception.


Read Full Abstract

Request Reprint E-Mail: seno@design.kyushu-u.ac.jp
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Genetic and Neurophysiological Correlates of the Age of Onset of Alcohol Use Disorders in Adolescents and Young Adults



Discrete time survival analysis was used to assess the age-specific association of event-related oscillations (EROs) and CHRM2 gene variants on the onset of regular alcohol use and alcohol dependence.
The subjects were 2,938 adolescents and young adults ages 12–25.

Results showed that the CHRM2 gene variants and ERO risk factors had hazards which varied considerably with age. The bulk of the
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Gender-Specific Gene–Environment Interaction in Alcohol Dependence: The Impact of Daily Life Events and GABRA2




Gender-moderated gene–environment interactions are rarely explored, raising concerns about inaccurate specification of etiological models and inferential errors.

The current study examined the influence of gender, negative and positive daily life events, and GABRA2 genotype (SNP rs279871) on alcohol dependence, testing two- and three-way interactions between these variables using multi-level
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FASD News - 33/2013


















NEWS and ARTICLES

Wort.lu (Luxembourg) - 16 percent of women in Luxembourg admit to drinking alcohol during pregnancy

According to a survey carried out by the Health Ministry at the Bohler Clinic and the Maternité Grande-Duchesse Charlotte between August and October 2012, 16 percent of the polled pregnant women consumed alcohol during their pregnancy.

Read more

KCSG (
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Biochemical Predictors of Delirium Tremens in Patients in Alcohol Withdrawal




To study whether routine blood parameters in patients with alcohol syndrome predict the risk of developing delirium tremens.

Biochemical parameters were collected and analysed in 212 patients attending a psychiatry department for inpatient alcohol detoxification treatment.

Differences between those who did, and did not, develop delirium were
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Sex-Specific Differences in the Development of Acute Alcohol-Induced Liver Steatosis in Mice





Results of several animal studies suggest that similar to humans, female rodents are more susceptible to chronic alcohol-induced liver disease (ALD). The aim of the present study was to determine whether female mice are more susceptible to acute alcohol-induced steatosis than male mice and to investigate possible mechanisms involved.

Male and female
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Blood Ethanol Levels of Nonabstinent Japanese Alcoholic Men in the Morning After Drinking and Their ADH1B and ALDH2 Genotypes




Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B, rs1229984) and aldehyde dehydrogenase-2 (ALDH2, rs671) affect ethanol (EtOH) metabolism and susceptibility to alcoholism.
We evaluated associations between ADH1B/ALDH2 genotypes and the blood EtOH levels of 805 Japanese alcoholic men in the morning after they had drunk within the previous 34 h.
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'Making recovery a reality through integrated mental health, drug and alcohol services'






A recent briefing on mental health, drug and alcohol services urges commissioners to tackle the poorly integrated support received by those with overlapping substance misuse and mental health needs, or 'dual diagnosis'.

The two page report was produced by The Centre for Mental Health, Drugscope and Alcohol Concern.

The briefing explores the idea of 'recovery', the new commissioning
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Critique 121: Differences between wine and other alcoholic beverages in terms of adverse consequences of alcohol consumption




The present study was based on questionnaire data related to alcohol intake that were obtained from just over one half of military conscripts from the general population who were invited to participate. Their average age was just over 19 years. “Risky single occasion drinking” (RSOD) was defined as consuming at least six standard drinks (10-12 g of alcohol/drink), and “At risk RSOD” was
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Beverage preferences and associated drinking patterns, consequences and other substance use behaviours

Studies about beverage preferences in a country in which wine drinking is relatively widespread (like Switzerland) are scarce. Therefore, the main aims of the present study were to examine the associations between beverage preferences and drinking patterns, alcohol-related consequences and the use of other substances among Swiss young men.

The analytical
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Predicting steep escalations in alcohol use over the teenage years: age-related variations in key social influences





This study examined how family, peer and school factors are related to different trajectories of adolescent alcohol use at key developmental periods.



Latent class growth analysis was used to identify trajectories based on five waves of data (from grade 6, age 12 to grade 11, age 17), with predictors at grades 5, 7 and 9 included as covariates.




Adolescents completed surveys during
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Alcohol use and abuse in young adulthood: Do self-control and parents’ perceptions of friends during adolescence modify peer influence? The TRAILS Study

To assess the influence of peer alcohol use during adolescence on young adults’ alcohol use and abuse, and to assess to what extent parents’ perception of their adolescent child’s friends and adolescent’s self-control modify this influence.


We analyzed data from the first, third, and fourth wave of a population-based prospective cohort study of 2230 adolescents conducted between 2001 and 2010 (
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News Release - NIH study finds chronic alcohol use shifts brain’s control of behavior




Chronic alcohol exposure leads to brain adaptations that shift behavior control away from an area of the brain involved in complex decision-making and toward a region associated with habit formation, according to a new study conducted in mice by scientists at the National Institutes of Health.

The finding provides a biological mechanism that helps to explain compulsive alcohol use and
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Journal of Studies on Alcohol and Drugs Volume 74, 2013 > Issue 5: September 2013




Editor's Corner: DSM-5—Ready or Not, Here It Comes [OPEN ACCESS]

Marc A. Schuckit


A Twin Study of Alcohol Dependence, Binge Eating, and Compensatory Behaviors [OPEN ACCESS]


Impact of Fathers' Alcohol Problems on the Development of Effortful Control in Early Adolescence

Request Reprint E-Mail: eiden@ria.buffalo.edu

Alcohol-Specific Parenting as a Mechanism of Parental
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Chronic alcohol produces neuroadaptations to prime dorsal striatal learning





Drug addictions including alcoholism are characterized by degradation of executive control over behavior and increased compulsive drug seeking. These profound behavioral changes are hypothesized to involve a shift in the regulation of behavior from prefrontal cortex to dorsal striatum (DLS). Studies in rodents have shown that ethanol
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Genome-wide association studies of maximum number of drinks




Maximum number of drinks (MaxDrinks) defined as “Maximum number of alcoholic drinks consumed in a 24-h period” is an intermediate phenotype that is closely related to alcohol dependence (AD). Family, twin and adoption studies have shown that the heritability of MaxDrinks is approximately 0.5.

We conducted the first genome-wide association (GWA) study and meta-analysis of MaxDrinks as a
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Global Actions: Commitments to Reduce Harmful Drinking. Auigust 21, 2013








Global Actions in Focus

discussing partnerships with government leaders in india



ICAP Country Coordinator in India Dr. Hetal Gandhi met with the Joint Commissioner of the Mumbai Traffic Police Mr. Vivek Phansalkar on August 13, 2013. Dr. Gandhi distributed copies of the recent India Initiatives booklet and discussed the status and progress of ongoing projects within India. The
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A Twin Study of Alcohol Dependence, Binge Eating, and Compensatory Behaviors



Rates of alcohol dependence are elevated in women with eating disorders who engage in binge eating or compensatory behaviors compared with women with eating disorders who do not report binge eating or compensatory behaviors and with healthy controls. Alcohol dependence, binge eating, and compensatory behaviors are heritable; however, it is unclear whether a shared genetic liability contributes
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Why Not Add Consumption Measures to Current Definitions of Substance Use Disorders? Commentary on Rehm et al. ‘Defining Substance Use Disorders: Do We Really Need More Than Heavy Use?’



The article by Rehm and colleagues in this issue of the Journal argues
that diagnoses of substance use disorders should be based solely on measures of consumption. Although the authors provide convincing arguments for inclusion of consumption measures in the diagnostic criteria for substance use disorders, we do not agree that diagnostic criteria should
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A Commentary on Defining Substance Use Disorders: Do We Really Need More Than Heavy Use?




Defining Substance Use Disorders as heavy use will help to reduce fruitless discussions about labeling, reduce stigma and increase the likelihood of people coming forward for help of whatever level of intensity best matches their needs.
Clinicians will still need to assess propensity for withdrawal symptoms and help the heaviest drinkers to work out
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Drinkaware 2012 report reviews impact of activities - but will health groups be convinced?




The industry funded alcohol education charityDrinkaware has released a 2012 impact report, detailing its recent activities and reported impacts on target groups. Report here (pdf).


Drinkaware's existence not surprisingly divides opinions; some health groups are sceptical of indsutry led intiatives, or raise concerns over a policy focus on education based approaches. Earlier this year
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Alcohol News - 33/2013








The Guardian (UK) - Public health: cutting a deal on the minimum price of alcohol

The fallout from the government u-turn on plain cigarette packaging and a minimum unit price for alcohol continues. To date, the Faculty of Public Health, the Association of Directors of Public Health and Birmingham city council have all withdrawn from the "public health responsibility deal".

Read more

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MEDIA RELEASE - MORE TO BE DONE TO TREAT DRUG AND ALCOHOL ABUSE








A Parliamentary Inquiry has found that more needs to be done if New South Wales is to better respond to the needs of individuals seeking drug and alcohol treatment.


The Inquiry by the General Purpose Standing Committee No. 2 was established last November to inquire into and report on the effectiveness of current alcohol and drug policies with respect to deterrence, treatment and
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News Release - Pilot Study Finds ER Patients Drinking High-Octane Beer




Budweiser, Steel Reserve, Colt 45, Bud Ice and Bud Light – were consumed in the highest quantities by emergency room patients, according to a new pilot study from researchers at The Center on Alcohol Marketing and Youth (CAMY) at the Johns Hopkins Bloomberg School of Public Health. Three of these are “malt liquors” with higher alcohol content than regular beer.
The pilot study, published by
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Alcohol Brand Use and Injury in the Emergency Department: A Pilot Study.














In an urban emergency department on weekend nights in 2010 and 2011, 105 interviews assessed feasibility of collecting alcohol brand consumption data from injured patients who drank within 6 h of presentation, with responses to the orally administered survey specifying 331 alcohol brands recorded on a netbook computer.

A Kruskal–Wallis test adjusted for tied ranks assessed
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Interactive map: Beer consumption per capita in 2012






Which state's residents drank the most beer in 2012?

The Beer Institute came out with its 2012 state consumption rankings on July 2, putting Wisconsin at No. 5 in per capita consumption by persons 21 years old or older.

Here's a visualization of the institute's findings. States are numbered from greatest to least per-capita beer consumption in 2012. Tap or hover over a state for more
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An Empirical Evaluation of the US Beer Institute’s Self-Regulation Code Governing the Content of Beer Advertising








We evaluated advertising code violations using the US Beer Institute guidelines for responsible advertising.
We applied the Delphi ratingtechnique to all beer ads (n = 289) broadcast in national markets between 1999 and 2008 during the National Collegiate Athletic Association basketball tournament games. Fifteen public health professionals completed ratings using quantitative scales
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ICAP Blue Book






The ICAP Blue Book: Practical Guides for Alcohol Policy and Prevention
Approaches offers a comprehensive guide to the key issues in alcohol policy
development and an integrated approach to prevention. It draws upon the best
available research and experience from around the world.


As a policy guide, the ICAP Blue Book is based on three key elements:




drinking patterns and their
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A Genome-Wide Association Study of Behavioral Disinhibition





We report results from a genome wide association study (GWAS) of five quantitative indicators of behavioral disinhibition: nicotine, alcohol consumption, alcohol dependence, illicit drugs, and non-substance related behavioral disinhibition.

The sample, consisting of 7,188 Caucasian individuals clustered in 2,300 nuclear families, was genotyped on over 520,000 SNP markers from Illumina’s
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New Report Recommends Public Health Focus on Harmful Drinking vs. Eliminating Consumption












The traditional public health perspective on alcohol and noncommunicable diseases (NCDs) is challenged in a new paper from the International Center for Alcohol Policies (ICAP), Alcohol misuse and global health: The case for an inclusive approach to harmful drinking. ICAP has announced the publication of the paper as part of a collection of submissions on the role of health in the
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Global Actions: Commitments to Reduce Harmful Drinking August










Global Actions in Focus


stimulants added to alcohol beverages:

Research review and discussion paper



The Stimulants Added to Alcohol Beverages: Research Review and Discussion paper was recently posted on the Beer, Wine and Spirits Producers’ Commitments website. The paper addresses the commitment to provide consumer information and responsible product innovation, and discusses
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Half of all drinkers exceed national guidelines




New research has further dispelled the myth that alcohol misuse is confined to a minority of Australians finding that over half (51.6%) of all drinkers consume alcohol in excess of the country’s guidelines.

Produced by the Centre for Alcohol Policy Research (CAPR) the research analysed the 2010 National Drug Strategy Household Survey to identify how many Australian drinkers consume in excess
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Alcohol questionnaires and HDL: Screening scores as scaled markers of alcohol consumption




Improving the quality of alcohol-related care requires practical approaches to assessing alcohol consumption to guide management and monitor outcomes. Given the increasing use of alcohol screening questionnaires to identify alcohol misuse it would be ideal if scores on screening questionnaires were also indicators of average alcohol consumption. However, the questionnaires were not designed
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Neonatal ethanol exposure results in dose-dependent impairments in the acquisition and timing of the conditioned eyeblink response and altered cerebellar interpositus nucleus and hippocampal CA1 unit activity in adult rats





Exposure to ethanol in neonatal rats results in reduced neuronal numbers in the cerebellar cortex and deep nuclei of juvenile and adult animals. This reduction in cell numbers is correlated with impaired delay eyeblink conditioning (EBC), a simple motor learning task in which a neutral conditioned stimulus (CS; tone) is repeatedly paired with a co-terminating unconditioned stimulus (US;
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The importance of age composition of 12-step meetings as a moderating factor in the relation between young adults’ 12-step participation and abstinence




Participation in 12-step mutual help organizations (MHO) is a common continuing care recommendation for adults; however, little is known about the effects of MHO participation among young adults (i.e., ages 18–25 years) for whom the typically older age composition at meetings may serve as a barrier to engagement and benefits. This study examined whether the age composition of 12-step meetings
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Minimum pricing: commons briefing note provides policy overview







A Commons standard note on minimum pricing was recently published, outlining 'minimum pricing' terminology and the policy context.


The briefing includes clarification on the differences between a 'below cost ban' and minimum unit pricing (MUP) and the various policy shifts over recent years. It also covers Scotland, where the SNP are pushing ahead with their MUP plans despitelegal
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A Qualitative Study of Alcohol, Health and Identities among UK Adults in Later Life




Increasing alcohol consumption among older individuals is a public health concern. Lay understandings of health risks and stigma around alcohol problems may explain why public health messages have not reduced rates of heavy drinking in this sector. A qualitative study aimed to elucidate older people's reasoning about drinking in later life and how this interacted with health concerns, in order
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Excessive Drinking Costs U.S. $223.5 Billion


A new study finds that excessive alcohol consumption cost the United States $223.5 billion in 2006, or about $1.90 per drink. By implementing effective community-based prevention strategies, we can reduce excessive alcohol consumption and its costs. > > > Read More
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Cumulative and Recent Psychiatric Symptoms as Predictors of Substance Use Onset: Does Timing Matter?





We examined two questions about the relationship between conduct disorder (CD), depression, and anxiety symptoms and substance use onset: (1) what is the relative influence of recent and more chronic psychiatric symptoms on alcohol and marijuana use initiation and (2) are there sensitive developmental periods when psychiatric symptoms have a stronger influence on substance use initiation?



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To investigate longitudinally the effect of alcohol consumption and related acute alcohol-related dysfunction on employment status






1143 men aged 25-55 years in regular paid employment and resident in the city of Izhevsk, Russia were interviewed between 2003-6 and then re-interviewed (2008-9) and their employment status ascertained.






Exposures of interest were baseline alcohol
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Trend analysis and modelling of gender-specific age, period and birth cohort effects on alcohol abstention and consumption level for drinkers in Great Britain using the General Lifestyle Survey 1984-2009









British alcohol consumption and abstinence rates have substantially increased in the last three decades. This study aims to disentangle age, period and birth cohort effects to improve our understanding of these trends and suggest groups for targeted interventions to reduce resultant harms.






Age, period, cohort analysis of repeated cross-sectional surveys using separate logistic and
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Welcome to the Alcohol Policy Information System





The Alcohol Policy Information System (APIS) provides detailed information on a wide variety of alcohol-related policies in the United States at both State and Federal levels. Detailed, state-by-state, information is available for the 33 policies listed below. APIS also provides a variety of informational resources of interest to alcohol policy researchers and others involved with alcohol
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AUDITOR-GENERAL’S REPORT COUNTING THE COST OF ALCOHOL ABUSE




The NSW Government does not estimate or report the total cost of alcohol abuse. The Audit Office of New South Wales’ sponsored research estimates it costs the government over $1 billion a year, or around $416 from each NSW household. > > > > Read More
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Status report on alcohol and health in 35 European countries 2013






People in the WHO European Region consume the most alcohol per head in the world. In the European Union (EU), alcohol accounts for about 120 000 premature deaths per year: 1 in 7 in men and 1 in 13 in women. Most countries in the Region have adopted policies, strategies and plans to reduce alcohol-related harm. In 2012, the WHO Regional Office for Europe collected information on alcohol
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Alcohol consumption and electrocardiographic left ventricular hypertrophy and mediation by elevated blood pressure in older Chinese men: The Guangzhou Biobank Cohort Study








Chinese people have a markedly lower alcohol consumption than people in the West. Whether alcohol consumption at such levels is associated with left ventricular hypertrophy, and the role of blood pressure (BP) in this relationship is unclear. We investigated the association between alcohol consumption and electrocardiographic left ventricular hypertrophy (ECG-LVH) and the mediating role
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Assessing the Effects of Medical Marijuana Laws on Marijuana and Alcohol Use: The Devil is in the Details




This paper sheds light on previous inconsistencies identified in the literature regarding the relationship between medical marijuana laws (MML) and recreational marijuana use by closely examining the importance of policy dimensions (registration requirements, home cultivation, dispensaries) and the timing of them. Using data from our own legal analysis of state MMLs, we evaluate which features
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μ-Opioid receptors in the nucleus accumbens shell mediate context-induced reinstatement (renewal) but not primed reinstatement of extinguished alcohol seeking.





Opioid antagonists reduce the rate of relapse to drinking in clinical trials and reduce reinstatement in animal models of drug seeking. However, the neuroanatomical locus for this effect remains poorly understood.

We examined the role of nucleus accumbens shell (AcbSh) μ-opioid receptors in two different forms of recovery of alcoholic beer seeking. Rats were trained to nosepoke for
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Assessment and management of alcohol dependence and withdrawal in the acute hospital







This brief guide to the assessment and management of alcohol dependence and withdrawal in the acute hospital is derived from the relevant NICE Guidance on the treatment of alcohol problems. It usefully summarises; Identification, assessment of the need for medically assisted withdrawal and the management of risk of Wernicke’s encephalopathy.


Read Full Guide (PDF)
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Alcohol News - 32/2013

















UPI.com - Using alcohol to self medicate increases addiction risk

Using alcohol as though it were a medication -- to ease feelings of depression -- are more likely to become alcohol dependent, U.S. researchers say.

Read more

News-Medical.net - Higher cigarette tax leads to lower alcohol consumption!

While people may think, that since that one intoxication could be
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News Release - Alcohol use among pregnant women in substance abuse treatment drops in past decade, but illicit drug use rises





According to a new report by the Substance Abuse and Mental Health Services Administration (SAMHSA) the percentage of pregnant woman in substance abuse treatment using alcohol (with or without drug use) dropped from 46.6 percent to 34.8 percent over a ten year period. However, the report also shows that the percentage of substance abuse admissions involving pregnant women using drugs (without
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'Stick to the facts': Alcohol Concern call for tougher regulation on alcohol advertising






Alcohol Concern have called for a major shake up of the alcohol advertising regulation framework to achieve a better balance between public health concerns and commercial freedoms.

The 'Stick to the facts' report says advertising creates social norms around alcohol and promotes the normalisation of drinking in society. Exposure to alcohol marketing is linked to consumption, particularly in
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NIH issues online course on screening youth for alcohol problems




A new online training course will help health care professionals conduct fast, evidence-based alcohol screening and brief intervention with youth. The National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health, produced the course jointly with Medscape, a leading provider of online continuing medical education.

“Just in time for back-to-school
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Medical Marijuana Laws, Traffic Fatalities, and Alcohol Consumption(



To date, 19 states have passed medical marijuana laws, yet very little is known about their effects. The current study examines the relationship between the legalization of medical marijuana and traffic fatalities, the leading cause of death among Americans ages 5–34.

The first full year after coming into effect, legalization is associated with an 8–11 percent decrease in traffic fatalities.
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Alcohol consumption as a preventive factor for developing rheumatoid arthritis: a dose-response meta-analysis of prospective studies




To summarise the evidence regarding the dose-response association between alcohol consumption and risk of rheumatoid arthritis (RA).



Studies were identified from search of MEDLINE, Embase and Web of Science databases between 1 January 1946 and 10 April 2013, and from review of the conference abstracts and the reference
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Racial Differences in Type of Alcoholic Beverage Consumed During Adolescence in the Pittsburgh Girls Study





White, compared with Black, adolescents have higher rates of alcohol use and show more rapid increases in alcohol use. Racial differences in type of alcohol beverage (i.e., beer, wine, and liquor) consumed by youth have received scant attention, and little is known regarding changes in type of alcohol beverage consumed during adolescence, when experimentation may transition to more regular
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Increased Cigarette Tax is Associated with Reductions in Alcohol Consumption in a Longitudinal U.S. Sample



Cigarette taxation has been recognized as one of the most significant policy instruments to reduce smoking. Smoking and drinking are highly comorbid behaviors, and the public health benefits of cigarette taxation may extend beyond smoking-related outcomes to impact alcohol consumption. The current study is the first to test whether increases in cigarette taxes are associated with reductions in
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Characterizing Gender Differences in Treatment Seekers




Available evidence suggests women may be more vulnerable to the effects of chronic alcohol consumption than men. The few investigations of gender differences in treatment-seeking populations have often involved study samples restricted by selection criteria (e.g., age, education). The current study examined gender differences in a heterogeneous sample of individuals seeking treatment for a
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Group management of pharmacotherapy for alcohol dependence: Feasibility and impact on adoption


One of the barriers to initiating patients on medications for alcohol dependence is concern about the work involved in providing ongoing medication management. In this brief report, we describe our initial experiences with a medication management group, initially implemented to provide continued access during a staffing shortage.

We describe the group structure and functioning, and provide
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Ethanol Self-Administration in Serotonin Transporter Knockout Mice: Unconstrained Demand & Elasticity



Low serotonin function is associated with alcoholism, leading to speculation that increasing serotonin function could decrease ethanol consumption. Mice with one or two deletions of the serotonin transporter (SERT) gene have increased extracellular serotonin.
To examine the relationship between SERT genotype and motivation for alcohol, we compared ethanol self-administration in mice with zero
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Does Science Show What 12 Steps Know?







Science has never revealed as much about addiction—potential genetic causes, influences, and triggers, and the resultant brain activity—or offered as many opportunities and methods for initial treatment as it does now.



Even so, the grassroots 12-step program remains the preferred prescription for achieving long-term sobriety.

Since the inception of Alcoholics Anonymous (A.A.)—the
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Helping Yourself to Recovery






Helping others has been an integral part of the folk wisdom about addiction recovery for more than 250 years. From early Native American recovery circles, early Euro-American recovery mutual aid societies and the 20th century advent of 12-Step recovery through the ever-widening menu of religious, spiritual and secular recovery pathways, the message has been clear: help yourself by helping
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Facial Dysmorphism Across the Fetal Alcohol Spectrum






Classic facial characteristics of fetal alcohol syndrome (FAS) are shortened palpebral fissures, smooth philtrum, and thin upper vermillion. We aim to help pediatricians detect facial dysmorphism across the fetal alcohol spectrum, especially among nonsyndromal heavily exposed (HE) individuals without classic facial characteristics.
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How Online Counselling Can Help You (Caroline Bronte)

Sorry, I could not read the content fromt this page.Sorry, I could not read the content fromt this page.
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Help me sleep (ethan chong)

Do you know that prevention is better than cure? In fact, if you prevent insomnia from happening on you, you can lead a better life! Today in this article, I will provide you some tips and tricks that can help you sleep in no time! (I used these methods to help me sleep before, so have no worries about them as they are a proven and effective method for preventing insomnia.)

Here are the tips and tricks that I used to help me sleep:

Help me sleep method #1: Avoid coffee and other sources of caffeine
Do you know why we need to avoid coffee? This is because of the stimulating effect of caffeine which can last for many hours and interfere with your ability to fall asleep at night. Hence, you MUST avoid all sources of caffeine so that you can fall asleep more easily at night. There are many other sources of caffeine other than coffee, examples of foods that contain caffeine are, tea, soft drinks, some brands of aspirin and chocolate.

Help me sleep method #2: Limit your alcohol intake
Limiting your alcohol intake is an important factor in helping you sleep better. This is due to the alcohol's ability to disrupt brain electrical activity and undermine normal sleep architecture by suppressing the rapid eye movement stage of sleep.

Help me sleep method #3: Avoid or limit your naps
Try to avoid taking long naps in the afternoon. If you really want to refresh yourself, take a nap between 30 minutes - 1 hour. Do NOT sleep too much because napping can disrupt your natural sleep cycle and prevent you from feeling tired enough to fall asleep when you really want it, which is at night.


Help me sleep method #4: Don't force yourself to sleep if you are really not tired at all
This is the common mistake made by insomniacs. Do you know why I asked you not to force yourself to sleep if you are really not tired at all? It is because if you are not tired, you will set yourself up for tossing and turning in your bed, which is not what you wanted. Here's a tip: If you are awake after twenty minutes or so, get out of your bed and do something quiet and non-stimulating. After you start to feel tired, return back to your bed and try to sleep again.

Help me sleep method #5: Review your medications
Not all medications provided by your doctors are good for your sleep! There are some over-the-counter drugs which contain stimulants such as caffeine or pseudoephedrine that can prevent you from getting a good sleep! Hence, try to review your medications with your doctor before you take them before you sleep.

The above tips written are the proven techniques that I used to help me sleep. I hope that these tips and tricks to prevent insomnia can also help you sleep better. However, if your sleep problems persist, I would recommend that you seek a doctor because you might have a treatable underlying illness that's interfering with your sleep such as obstructive sleep apnea or depression.

Ethan Chong is a sleep expert who has been training and teaching people professionally on how to cure and treat their sleep disorders easily and instantly. Have a question related to sleep insomnia? Ask Ethan Chong at http://www.SleepWellSecrets.com. The author grants full reprint rights to this article. You may reprint and electronically distribute this article so long as its contents remain unchanged and the author's byline remains in place.
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Hunt for the best language translation services (Jason Hill)

With so many languages used in the international market, language translation services has become a must for companies operating at international level in order to sustain in the market and have effective communication. Effective communication in varied languages has become a primary stimulus in global marketing for the understanding of business documents that are often in the regional language of the area you are doing business in. It is almost next to impossible to have a strong hold on the number of languages needed to have communication with clients of different regions. This is where the interpreter services prove to be very helpful.

With the high demand of these services, there are numerous companies that offer these services with high quality. You can refer to the Yellow Pages or a business directory pertaining to your region to have contact details of such companies. Internet can also prove to be beneficial in these situations. You can find numerous listings of different agencies via the search engines. Here are few things that you should keep in mind while hiring the service of a language translator agency.

- Ensure that the company has enough credibility in the market and provides distinguished translation language service. Price should not always be the element of comparison. It is better to pay a little more for a better service than to get below standard services at a cheap price.


- Translation is a job where one needs to have maximum knowledge and expertise. Any mistranslation can cause you huge losses in your business. So it is advisable to look for certified translators. You should always check the service provided by the agency by asking for a sample work before assigning it the job.

- Confidentiality of information is something that should be given top priority. The assigned translation company should not reveal your information to any outsider at any cost or situation. You should make sure that the contract highlights such crucial points regarding the safeguarding of your company's document.

- Look for any additional service provided by the company like remote video interpretation. Such services can often come in handy in many situations. If an agency offers a bit more than the usual then it also tells a lot about its diversity and expertise in that particular field.

After conforming the above mentioned points you can rest be assured about your translation company. The agency will provide you complete satisfaction with the job you assign, be it Spanish translation services or any other language.

The translation language service is now a prerequisite for global marketing and communication. You can now get the assistance of well trained and trusted translators.
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Effects of binge drinking on action cascading processes: an EEG study




High-dosage alcohol intoxication (i.e., binge drinking in humans) is an increasingly prevalent problem. Despite the well-known long-term consequences, the acute effects of high-dosage alcohol intoxication on cognitive control processes have not been investigated with respect to neurophysiological changes in humans.

We provide insights into the effects of high-dosage ethanol intoxication on
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The Advantages of Telephone Counselling (Caroline Bronte)

Sorry, I could not read the content fromt this page.Sorry, I could not read the content fromt this page.
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A Cross-Sectional Study of Attitudes About the Use of Genetic Testing for Clinical Care Among Patients with an Alcohol Use Disorder





Modification and individualization of medical treatments due to genetic testing has the potential to revolutionize healthcare delivery. As evidence mounts that genetic testing may improve treatment decisions for patients with alcohol use disorder (AUD), we explored patient concerns and attitudes toward genetic testing.

Subjects of two USA cross-sectional AUD studies were surveyed regarding
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Pellagra Encephalopathy in the Context of Alcoholism: Review and Case Report





The aim of the study was to review and describe the Alcoholic Pellagra Encephalopathy, a severe neuropsychiatric condition caused by a combination of niacin (vitamin B3) deficiency and alcohol abuse.

PsychInfo, Medline and Embase databases were searched for peer-reviewed studies addressing this illness.A historical and conceptual review of the psychopathological aspects of this condition is
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Defining Substance Use Disorders: Do We Really Need More Than Heavy Use





The aim of the study was to explore whether the concept of heavy substance use over time can be used as definition of substance use disorder.

Narrative review.

Heavy use over time clearly underlies the neurobiological changes associated with current thinking of substance use disorders. In addition, there is evidence that heavy use over time can explain the majority of social problems and
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ATTC Third Thursday iTraining for August 2013 - Neurobiology of Addiction

















Thursday, August 15, 2013 2:00 PM - 3:30 PM EDT

Webinar Registration


Neuroscience research during the last twenty years has fundamentally changed
our understanding of addiction. These new insights have elucidated many of the
neurobiological changes that occur in the brain after long term drug use. It is
now thought that these changes that are fundamental and long lasting
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How do you fix a relationship to Make Men crave for you ? (albert corey)

Sorry, I could not read the content fromt this page.Sorry, I could not read the content fromt this page.
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Differential Striatal Dopamine Responses Following Oral Alcohol in Individuals at Varying Risk for Dependence


The neurobiology of risk for alcohol use disorders (AUDs) remains poorly understood. Individual differences in vulnerability, though, have been indicated by subjective responses to alcohol ingestion and personality traits.



To investigate the relationship between these features and striatal dopamine (DA) responses to alcohol, we studied 26 healthy young social drinkers (21.3 ± 3.0 years old;
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The Expression of KLF11 (TIEG2), a Monoamine Oxidase B Transcriptional Activator in the Prefrontal Cortex of Human Alcohol Dependence



The biochemical pathways underlying alcohol abuse and dependence are not well understood, although brain cell loss and neurotoxicity have been reported in subjects with alcohol dependence. Monoamine oxidase B (MAO B; an enzyme that catabolizes neurotransmitters such as dopamine) is consistently increased in this psychiatric illness. MAO B has been implicated in the pathogenesis of alcohol
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Prenatal Ethanol (EtOH) Exposure Alters the Sensitivity of the Adult Dentate Gyrus to Acute EtOH Exposure






Prenatal ethanol (EtOH) exposure results in a spectrum of structural, cognitive, and behavioral abnormalities, collectively termed “fetal alcohol spectrum disorders” (FASDs). The hippocampal formation, an area of the brain strongly linked with learning and memory, is particularly vulnerable to the teratogenic effects of EtOH. Prenatal EtOH exposure can lead to long-lasting impairments in the
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Sensory-Motor Deficits in Children with Fetal Alcohol Spectrum Disorder Assessed Using a Robotic Virtual Reality Platform




Fetal alcohol spectrum disorder (FASD) is associated with a large number of cognitive and sensory-motor deficits. In particular, the accurate assessment of sensory-motor deficits in children with FASD is not always simple and relies on clinical assessment tools that may be coarse and subjective. Here we present a new approach: using robotic technology to accurately and objectively assess motor
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Prenatal Alcohol Exposure Results in Long-Term Serotonin Neuron Deficits in Female Rats: Modulatory Role of Ovarian Steroids




Previous studies on male rodents found that prenatal alcohol exposure (PAE) decreases the number of serotonin immunoreactive (5-HT-ir) neurons in the brainstem. However, data on the effects of PAE in females are lacking. In light of known sex differences in responsiveness of the 5-HT system and known effects of estrogen (E2) and progesterone (P4) in the brain, we hypothesized that sex steroids
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Impact of Combined Prenatal Ethanol and Prenatal Stress Exposure on Anxiety and Hippocampal-Sensitive Learning in Adult Offspring






Prenatal ethanol (EtOH) and prenatal stress have both been independently shown to induce learning deficits and anxiety behavior in adult offspring. However, the interactive effects of these 2 developmental teratogens on behavioral outcomes have not been systematically evaluated.



We combined an established moderate prenatal EtOH consumption paradigm where Long-Evans rat dams voluntarily
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Evaluation of the Influence of Alcohol Dehydrogenase Polymorphisms on Alcohol Elimination Rates in African Americans


The relationship between alcohol dehydrogenase (ADH) polymorphisms and alcohol use disorders in populations of African descent has not been clearly established. This study examined the effect of ADH1B polymorphisms on alcohol metabolism and subjective response, following intravenous (IV) alcohol administration, and the influence of gender, recent drinking history, and family history of
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Major Depressive Disorder symptoms and causes

There are many reasons why you liked the depressive disorder. It is a State of mind, when individual stop thinking and his/her brain is poured in the series of negative thoughts. Sufferer developed tend to be quiet and introverted, some of the thoughts that always surrounds his/her brain is like committing suicide, smash things to pull out of anger and pain, hurting others and hurting themselves. Such people will be quite aggressive and could be harmful to everyone, no matter how close can be family, friends or colleagues.

When a person begins to feel symptoms of depression he keeps digging, until someone helps them and pulls them out of the situation. Such person fails to distinguish between relationships, behaviour and thoughts. They just want to get rid of their life or do something terrible, which would claim their senses. In most cases such people developed criminal mindset and they begin to make crime without objective or reason. They can kill someone or even kill himself without any reason.

There are many horrible aspects of the depressive disorder, and there are some disorders associated with it as a mood disorder or bipolar disorder, as it completely inhibits the sufferer's life into a living hell. The victim soon goes into the darker side of life and suffering the pain of being human. He/she will stop feeling for others and give people around them of any significance. They kept just about to think and think and finally go into the deep silence mode, where they even stop eating or drinking. That would be the worst situation for any person suffering from major depressive disorder which not only makes them mentally retired, but also their families and friends.

Occasionally, those who have this kind of depressive condition certainly find out of sounds or maybe mark other activities not perhaps associated with real life. This kind of phase is associated with depression; as you learn in addition to consider the person suffering from such a disease develop a sense of self hatred among them. a number of cases also declare that when someone actually watch television, they will consider it must transfer some form of uncertain feelings in their brain. In addition, you will find, there is a critical indicator referred to as psychosis, it means you are outside feel like perception associated with the truth. This is deadly when they are all together in the community. Should you or perhaps other people actually struggling with this phase is associated with atypical depression, including paranoia, psychosis, or any other kind of strange to imagine, it may require a specialist to treat this disorder and bring the victim to a normal state of mind.

Robert Westover is a well-known author who has covered a wide range of topics so far. He writes about important and useful topics such as Major Depressive Disorder and mood disorder, which has helped her to amass a huge reader base.
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News & updates Aug 2013: Olympics alcohol impact; alcohol stats at risk; Drink Driving rise; trade news & more









Here's some of the recent news happening over the last month or so:


The 2012 London Olympics had no significant impact on alcohol related harms, a report published by the Centre for Public Health says. See a PHE press releasewhich states 'the findings can be used in the future to support the use of interventions such as restricted advertising and controlled pricing strategies in event
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A Qualitative Study of Alcohol, Health and Identities among UK Adults in Later Life




Increasing alcohol consumption among older individuals is a public health concern. Lay understandings of health risks and stigma around alcohol problems may explain why public health messages have not reduced rates of heavy drinking in this sector.

A qualitative study aimed to elucidate older people's reasoning about drinking in later life and how this interacted with health concerns, in
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New figures released: Alcohol grows as risk factor for death and disability (corrected version)




The new study found that alcohol was the fifth leading risk factor for death and disability in 2010, accounting for 5.5% of disability adjusted life years (DALYs) lost globally, up from 3.5% in 1990. 67 risk factors have been studied and results are presented for 21 regions all over the world.





The Global Burden of Disease (GBD) study attempts to calculate which factors cause early deaths
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Global Actions: Commitments to Reduce Harmful Drinking. August 7, 2013














Global Actions in Focus

Q&A with mrs. lan hyong nguyen

drink driving initiatives in vietnam


Mrs. Lan Hyong Nguyen joined ICAP in October 2010 as the Country Manager for the Global Actions on Harmful Drinking initiatives in Vietnam. Before joining ICAP, she was the Country Manager for the Global Road Safety Partnership (GRSP) Vietnam. As Country Manager for Global Actions
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Conference - New Directions in the Study of Alcohol Group 2013



LOCATION
Birmingham
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News Release - NIH Study Explains Neuroscience of Habit Breaking






Recent research from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) sheds new light on habitual behaviors, specifically the circuits in the brain that allow mice to break from routine actions. Such shifting between old habits and new behavior aimed at accomplishing a particular goal are critical to flexible decision-making in everyday life. It also has important implications
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Adenosine signaling in striatal circuits and alcohol use disorders


Adenosine signaling has been implicated in the pathophysiology of alcohol use disorders and other psychiatric disorders such as anxiety and depression. Numerous studies have indicated a role for A1 receptors (A1R) in acute ethanol-induced motor incoordination, while A2A receptors (A2AR) mainly regulate the rewarding effect of ethanol in mice. Recent findings have demonstrated that dampened
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Conditions pertaining in Bipolar disorder

Mixed bipolar disorder is of two types. The one, which is a combination of two important symptoms of severe depression and Mania at the same time and another form is the rapid cycling. Each mode reveals its list of problems; as well as each disorder requires a specialist treatment for healing.

Combine disorder: in the initial phase, maniacal behavior is feeling hopeless outline mode. This specific apparently illogical mix requires extreme cure, otherwise it could develop constant psychosis or a suicidal habit can in the Sufferer. Some of the common symptoms associated with bipolar disorder is extreme desire to mix food, unpredictable mood swings, joint agitation, insecure behavior and many other such symptoms.

Rapid cycling: The actual condition of rapid cycling means unnatural extinct by four episodes in one year. They can occur at any time in a given year and do not have any fixed frequency. Episodes are nothing more than a State of mind, when a person loses cool feels shy and suffering from rapid mood swing. These situations are different from person to person and can be too short-sighted. However, episodes be fatal as it can cause serious damage to brain cells and damage the central nervous system. A person goes through such episodes will be very dangerous and unable to record between good and bad. Such a person should never be left alone and must always be in alertness.

The actual nature of the irregularities, involving both forms of bipolar disorder does, of course, the problem is very difficult to deal with, as well as more challenging to take care of when comparing with other forms in this mode. It should also be noted that certain situations makes it far more difficult for people to identify bipolar disorder. The first symptoms are so common as any other disorders, therefore, people ignore them to treat it like a common mood disorder or a mental stress.

Important issues in the context of bipolar disorder

The most effective method for the treatment of bipolar disorder is the Sufferer must receive assistance through guidance and counselling and by taking proper medication. It is also important that such people throughout their daily lives for their improvement. Depending on the single put together your special functions involving bipolar disorder can certainly vary between mildly detracts from his common function to get completely unbearable.

Robert Westover is a well-known author who has covered a wide range of topics so far. He writes about important and useful topics such as Major Depressive Disorder and mood disorder, which has helped her to amass a huge reader base.
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5 Happy events that can cause Stress (Caroline Bronte)

Sorry, I could not read the content fromt this page.Sorry, I could not read the content fromt this page.
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he Association of Mild, Moderate, and Binge Prenatal Alcohol Exposure and Child Neuropsychological Outcomes: A Meta-Analysis





The objective of this review is to evaluate the literature on the association between mild, moderate, and binge prenatal alcohol exposure and child neurodevelopment.



Meta-analysis with systematic searches of MEDLINE (1970 through August 2012), EMBASE (1988 through August 2012), and PsycINFO® (1970 through August 2012) and examination of selected references.




From 1,593 articles, we
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Female Rats Display Enhanced Rewarding Effects of Ethanol That Are Hormone Dependent





Ethanol (EtOH) abuse is a major health and economic concern, particularly for females who appear to be more sensitive to the rewarding effects of EtOH. This study compared sex differences to the rewarding and aversive effects of EtOH using place-conditioning procedures in rats.



Separate groups of adult (male, female, ovariectomized [OVX] female) and adolescent (male and female) rats
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Deletion of Prkcz Increases Intermittent Ethanol Consumption in Mice







Prkcz has been identified as a gene whose expression is positively correlated with ethanol (EtOH) consumption in mice and is also induced by EtOH. Two proteins are produced from Prkcz: protein kinase M zeta (PKMζ), which is expressed in the nervous system and protein kinase C zeta (PKCζ), which is expressed in other tissues. We examined Prkcz−/− mice that lack PKCζ and PKMζ to investigate
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Understanding Depression

Depression is a disease which affects individuals and families all over the world in terrible ways - sometimes, tragically, to the extent where sufferers are lost to suicide. This disorder is one which is still not understood well by the general public, although the medical community has developed a much better understanding of what it is, what causes it and how best to treat it in recent years.

It's important to understand that first and foremost depression is a real disorder, not simply someone being 'down in the dumps.' It is this misconception that sufferers can simply 'get over it' that causes many sufferers to avoid seeking the treatment they desperately need. This is a misconception that needs to be corrected - and thankfully, more people are beginning to be more open-minded about it and more understanding of what its sufferers have to go through.

What many people also don't realise is that there are different types of depression. The disorder we typically associate with the word depression is what is clinically known as 'major depression.' This is distinguished from bipolar depression. Major depression is characterised by consistently low moods, whereas bipolar typically involves rapid changes between low moods and episodes of high-intensity, frenetic behavior. Bipolar depression is also known as manic, because of this flux between depressed and manic states.

So how do you recognise this disorder? It's important to know the signs and symptoms so you can pick up on it not only in others, but in yourself (many people suffering this don't actually consider that they have the disorder. This is partly because some symptoms don't fit with the widespread misconceptions about the disorder.)

In order for a diagnosis of major depression to be made, the low moods need to have been occurring consistently for a long period of time - generally longer than 6 months before medications will be prescribed. It can be triggered by a difficult life event, although often there are other underlying causes which build up to a person becoming depressed.

Aside from the typical 'blue mood,' other symptoms include consistent feelings of hopelessness, loss of self esteem and a feeling that life is pointless. Changes in appetite are common, and sufferers also often find they lose interest in all activities - even activities which they previously enjoyed a great deal. Sleeping problems and a reduction in sex drive are other common indicators to keep an eye out for.

For more help understanding depression, please visit What Is Depression?

Richard Atchison Photo Richard Atchison, raised in New Zealand, graduated in 2002 from Auckland High School. A Presidential Scholar, he entered Auckland State University that autumn as an English major, with an emphasis in Literary Studies. Presently, an article contributor for various sites. What Is Depression?
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Alcohol News - 31/2013








The Local (Norway) - Norway risks even higher
booze taxes



Norway is considering imposing even higher taxes
on alcoholic drinks, a move that would bring it within a whisker of becoming
world's most expensive place for a tipple.Read
more



The Foreigner (Norway) - Norway government
alcohol monopoly eyes tax free



Vinmonopolet is considering moving into the
airport alcohol
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FASD News - 30/2013








NEWS and ARTICLES



SBS (Australia) - Foetal alcohol syndrome
victim calls on pregnant women not to drink



When it comes to the dangers of drinking alcohol
while pregnant, the message may not be getting through. Australian researchers
say only two out of three women know that alcohol can affect their unborn
child.



Read
more



Parent Herald - Alcohol During Pregnancy
Damages
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News Release - New insight on how the brain forms habits




New data offers a glimpse into the neurobiological mechanisms underlying the formation of habitual actions, such as addiction to alcohol.
In a study conducted in mice and rats, scientists in NIAAA’s Laboratory for Integrative Neuroscience examined the cellular basis for learning and memory in the dorsolateral striatum, a part of the brain involved in habit learning. A particular receptor in
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Why is it Necessary to Conduct Nicotine Test at Home? (Drugteststrips)

Nicotine, alcohol and illegal drug abuse is found to be more causative factor for deaths than any other problem in the United States. Nicotine is a nervous system stimulant and is addictive both physically and psychologically. With increase in tobacco consumption, there has been a necessity to detect the abusing individuals. Earlier, Nicotine testing was possible only in sophisticated hospitals and commercial laboratories. However, these days there are special home drug test kits that help you to detect nicotine abuse at home. Here is some information which helps you know the importance of Nicotine testing at home.

Tobacco-leading preventable cause of premature death
Tobacco abuse causes health problems such as bronchitis, pneumonia, brain and heart strokes, and other cardiovascular diseases. It is also responsible for mouth, throat, larynx, esophagus, pancreas and stomach cancers that may lead to death and hence is considered a leading preventable cause of premature death. Tobacco smoking results in more than 400,000 deaths in the United States every year. It is hence important to prevent Nicotine abuse among people. Conducting Nicotine test at home regularly can help reduce tobacco abuse.

Millions of smokers in US
Nicotine abuse in US has become common. The National Survey on Drug Use and Health states stated that there were about 58.7 million cigarette smokers aged 12 or above in 2009. This contributed to about 23.3 percent of the population. Cigarette smoking was found to be more common among unemployed adults aged 18 or older and constituted about 41.9%.

Effects of Tobacco abuse

Nicotine
The chief component of tobacco, activates adrenaline that in turn stimulates the central nervous system. This increases blood pressure, respiration, and heart rate. Nicotine also affects brain pathways that control pleasure and reward.

Tobacco smoking causes lung diseases such as pneumonia, chronic bronchitis and emphysema. It also increases the risk of heart diseases. Different hazardous chemicals including carcinogens in the smoke cause mouth, liver, and stomach cancers. Increased risk of diseases at earlier stages of life due to the abuse leads to premature deaths. Nicotine abuse also affects the personal and social life of the individuals. It is hence important to identify the abusers at primitive stages.


How to identify the abusers?
Tobacco abuse among your family members can be identified by certain signs and symptoms. Some of them include:

Smell of tobacco
Stained teeth or fingers
Shortness of breaths
Dizziness
Headache
Irritability
Loss of appetite
Frequent cough
Nausea
Sleep disturbances

Once you identify these signs, conduct a nicotine test at home to confirm the abuse.

How to conduct the test?
It is very easy to conduct a Nicotine test at home. Different types of kits are available for conducting urine, saliva and hair tests that detect the presence of Cotinine
a metabolite of Nicotine.

Urine test
Urine test is the most common method for testing Nicotine. It can detect cotinine for two to four days after tobacco use. The concentration of cotinine is higher in urine compared to saliva or blood. So, many home test kits are designed to detect cotinine in urine. The testing materials of the kit react with cotinine of the sample and give a positive or negative result.

Saliva test
It is a cheap and non-invasive method. A saliva sample is taken from the individual through a mouth swab. The saliva test kit checks for the presence of nicotine and cotinine. They can be detected for up to two to four days after use. As it is difficult to cheat the test by adulteration, it is considered to be ideal test that can be conducted at home.

Hair test
In this method, hair taken from any part of the body is checked for the presence of cotinine. The detection time for cotinine using hair test is more when compared to the fluid tests. The test is capable of detecting nicotine use for up to 90 days.

How reliable are drug test kits?
Home Nicotine test kits provide quick and accurate results. Some of them are sold in the market only after the approval of Food and Drug Administration (FDA). Hence, they are found to be more reliable and can be used safely at home.

It is most important for parents to detect tobacco abuse in their children. Nicotine test kits serve this purpose well by enabling them to conduct the test in privacy and comfort.

Processing ...
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Phospholipase A2, Oxidative Stress, and Neurodegeneration in Binge Ethanol-Treated Organotypic Slice Cultures of Developing Rat Brain






Brain neurodamage from chronic binge ethanol (EtOH) exposure is linked to neuroinflammation and associated oxidative stress. Using rat organotypic hippocampal–entorhinal cortical (HEC) slice cultures of developing brain age, we reported that binge EtOH promotes release of a neuroinflammatory instigator, arachidonic acid (AA), concomitant with neurodegeneration, and that mepacrine, a global
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Risk of Injury from Drinking: The Difference Which Study Design Makes






The magnitude of risk of injury from drinking, based on emergency department (ED) studies, has been found to vary considerably across studies, and the impact of study design on this variation is unknown.



Patients were interviewed regarding drinking within 6 hours prior to the injury or illness event, drinking during the same time the previous week, and usual drinking during the last 30
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Selectively Bred Crossed High-Alcohol-Preferring Mice Drink to Intoxication and Develop Functional Tolerance, But Not Locomotor Sensitization During Free-Choice Ethanol Access





Crossed high-alcohol-preferring (cHAP) mice were selectively bred from a cross of the HAP1 × HAP2 replicate lines and demonstrate blood ethanol concentrations (BECs) during free-choice drinking reminiscent of those observed in alcohol-dependent humans. In this report, we investigated the relationship between free-choice drinking, intoxication, tolerance, and sensitization in cHAP mice. We
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Dominance of the Inactive Asian Variant Over Activity and Protein Contents of Mitochondrial Aldehyde Dehydrogenase 2 in Human Liver





It has been well documented that a variant allele of mitochondrial aldehyde dehydrogenase 2 (ALDH2), ALDH2*2, commonly occurs in East Asians but rarely in other ethnic populations. This unique allelic variation significantly influences drinking behavior and susceptibility to development of alcoholism. Previous structural, functional, and cellular studies indicate that the resulting variant
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Alcohol Awareness Week 2013 runs 18-24 November; Alcohol Concern conferences




Alcohol Concern are promoting Alcohol Awareness Week (AAW) 2013 to take place from 18-24 November, encouraging local areas to promote conversations and awarenss of alcohol and its impact. Alcohol Concern have produced an outline of ideas and materials for organisations [pdf] who might wish to take part. Last year we reviewed Alcohol Awareness Week 2012 including a variety of twitter and local
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Learn Neuro Linguistic Programming to Solve Your Own Problems And Alter Your Life

Many people who want to discover NLP have no idea where to start. A number of them hit the actual books like grade-A college students. Others go to week-long workshops someplace. And some might purchase Neuro linguistic programming home research courses on the internet.

To each their own, I always state. After all, exactly what matters the majority of is that you possess the drive and also the desire to discover NLP. This alone is sufficient to get you via pretty much something.

However, if you aren't completely clear on how much you need to commit to Neuro linguistic programming, then perhaps some enlightenment is in order.

What NLP is actually

To learn Neuro linguistic programming, it's useful to understand its origins very first. NLP means Neuro-Linguistic Programming. This began within the 1970's whenever co-founders Richard Bandler as well as John Grinding machine decided to read the art associated with improving individual's lives.

It may sound a little too wide and a small too trusting now, however nothing had been off limits towards the field associated with psychotherapy after that. I suppose you can say that the actual 1970's would be a very exciting here we are at ideologies such as NLP. Everyone was just finding the power of alter and self-improvement.

Neuro linguistic programming Techniques

Within the decades, Neuro linguistic programming techniques happen to be tweaked to match the needs and desires of the individual person. Consequently, NLP presently has a host of self-improvement techniques under its belt.

In the simple artwork of anchoring (that involves the organization of pictures and feelings) to the numerous techniques associated with rapport (including mirroring techniques among others), Neuro linguistic programming has something for almost all kinds of scenario.

How Neuro linguistic programming can help you

If you wish to learn Neuro linguistic programming, you need to understand it's as good as having a transformation.

If you have always been scared of public speaking, for instance, NLP may push you to definitely take control of your concern. If you want to be a successful business owner, NLP can help turn you into a person who is an expert at company negotiations.

To understand NLP may appear a little modern for some, but that is only simply because they haven't been brought to it however. However, it isn't really because alien an idea as exactly what some may be thinking.

Neuro linguistic programming basically can help you take control of your existence. It helps the thing is things inside a different mild. It helps the thing is "you" in a various light. As well as your perspective is the reason why all the difference on the planet.

Visit NLP power training to know more about the benefits you attain by practicing neuro linguistic programming like confidence in public speaking for becoming a successful business personal as is mentioned above in the post.
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Adolescent substance use and peer use: a multilevel analysis of cross-sectional population data






Limited evidence exists concerning the importance of social contexts in adolescent substance use prevention. In addition to the important role schools play in educating young people, they are important ecological platforms for adolescent health, development and behaviors. In this light, school community contexts represent an important, but largely neglected, area of research in
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Sex chromosome-wide association analysis suggested male-specific risk genes for alcohol dependence





Alcohol dependence is more common among men than among women. Potential
explanations for this include the role of genes in sex chromosomes (X and Y). In
the present study, we scanned the entire Y chromosome and its homologs on the X
chromosome in men to identify male-specific risk genes for alcohol
dependence.


Two thousand nine hundred and twenty-seven individuals in two
independent
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Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent.

.


We have previously reported a top-ranked risk gene [i.e., serine incorporator 2 gene (SERINC2)] for alcohol dependence in individuals of European descent by analyzing the common variants in a genome-wide association study. In the present study, we comprehensively examined the rare variants [minor allele frequency ] in the NKAIN1-SERINC2 region to confirm our previous finding.

A discovery
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Help Understand Bipolar Disorder Symptoms

Male depression - what exactly does it mean, and how to males experience it differently from women? It comes as a surprise to many people to learn that men and women actually experience it very differently, often feeling very different symptoms and displaying different behaviours. It can be particularly difficult for men as the symptoms of male depression are often quite far from the common conceptions people have developed about how clinical depression looks. The words used can be very confusing, because although the word depression suggests a consistently low and 'sad' mood, it can often manifest in males in the form of agitation and anger.

Depression in men can be particularly hard to diagnose for these reasons, and very often men don't even recognise that they may be suffering from it. This is why it's so important to ensure a wider understanding of how the disorder manifests in men, how it can be controlled and how to find a way through it.

However, although the disorder can show different symptoms in men it's important to keep in mind that what most people think of as 'typical' symptoms are generally still present and dominant in most cases - for example, a loss of enthusiasm for formerly enjoyable activities, loss of interest in sex and consistently 'down' moods, along with recurring thoughts of death and suicide.

So how can you help someone you know who may be suffering from depression - or what can you do if you're a man and you think you might have depression? It's important that if a friend of family member may be suffering, you approach the situation cautiously, as some men may go into denial over having a problem. This denial can sometimes take on an angry form and cause the person to withdraw from you. It's important to broach the subject carefully and be prepared to explain how their behaviour lines up with common symptoms if necessary.

If you believe you might be suffering from depression you should talk to your doctor about potential treatment paths for you, which typically involve some therapy work and often medication (although that's not always the case). In the meantime, it's a good idea to try to avoid stressful situations if possible - while there are often many underlying factors that cause it, being put under pressure can trigger an episode.

Click here to learn more about bipolar disorder symptoms.

Richard Atchison Photo Richard Atchison, raised in New Zealand, graduated in 2002 from Auckland High School. A Presidential Scholar, he entered Auckland State University that autumn as an English major, with an emphasis in Literary Studies. Presently, an article contributor for various sites. bipolar disorder symptoms
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Flourish Homes- Recover And Rediscover Yourself

Drugs is the biggest enemy of human kind as it has destroyed the lives of millions of people and their families. Once you get in the claws of this habit, it would not be possible for you to free yourself from it. Many young people these days are addicted to drugs especially, lot of young girls and woman are getting this awful habit of taking drugs. In some past years there is a huge increase in number of drug cases, the biggest reason for this rise is the peer pressure, by friends. The another reason due to which these young people get addicted to drugs is loneliness. Especially if addict is a girl or women, then it's definitely a case of loneliness These young girls and woman don't know that not only they are playing with their life, but they are also hurting the emotions of their loved ones.

Drug addicts cannot be totally blamed for it as in such a situation it's difficult for a person to differentiate between right and wrong. In such a situation the most important thing for a drug addict is the support of friends and family, as they can help them to quit this habit. In such situation, instead of sending them to a typical rehabilitation center you should look for a place or rehabilitation center which is especially designed for women and where they don't even feel that they are here for treatment. It should be like a home away from home where they can do whatever they want and should have total freedom. It should provide the following amenities:-

Drug and Alcohol CounselingCase Management ServicesJob Search/ResumeCourt Liaison servicesRelapse Prevention CourseSelf Esteem Workshop Healthy Relationships Course

Aforementioned amenities can help drug addicts to regain their lost self esteem, and realize them that how much their life is important for their family and friends. It should also have the facilities of yoga and meditation classes as this will not only help them in soothing their mind, body and soul, but also help them to stay fit and getting rid of their drug addiction much quickly. It should also have phone and internet access so that they talk to their friends and family whenever they feel like. This will not only help them to remain in touch with them, but also motivate and remind them to get rid of their addiction as soon as possible so that they can go back home. At last, it should have a healthy living environment with all basic facilities which make them feel comfortable and help them to rediscover themselves.

Anoop Kumar Srivastava Photo FLOURISH CREATES a positive, loving, healthy living environment, fully furnished for 7 women, which provides safety and security while they begin their journey in recovery. Flourish Homes intents is to be a fully funded program provided for women through out Santa Clara County area. Flourish Homes is in the process of becoming a Non Profit Organization. Rate this Article

Flourish Homes- Recover And Rediscover YourselfNot Rated Yet

Anoop Kumar Srivastava has published 46 articles. Article submitted on February 22, 2013. Word count: 429

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Proteomic Approaches and Identification of Novel Therapeutic Targets For Alcoholism







Recent studies have shown that gene regulation is far more complex than previously believed and does not completely explain changes at the protein level. Therefore, the direct study of the proteome, considerably different in both complexity and dynamicity to the genome/transcriptome, has provided unique insights to an increasing number of researchers.

During the past decade,
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Beer Flavor Provokes Striatal Dopamine Release in Male Drinkers: Mediation by Family History of Alcoholism




Striatal dopamine (DA) is increased by virtually all drugs of abuse, including alcohol. However, drug-associated cues are also known to provoke striatal DA transmission- a phenomenon linked to the motivated behaviors associated with addiction. To our knowledge, no one has tested if alcohol’s classically conditioned flavor cues, in the absence of a significant pharmacologic effect, are capable
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Determination of Genotype Combinations That Can Predict the Outcome of the Treatment of Alcohol Dependence Using the 5-HT3 Antagonist Ondansetron






The authors previously reported that the 5′-HTTLPR-LL and rs1042173-TT (SLC6A4-LL/TT) genotypes in the serotonin transporter gene predicted a significant reduction in the severity of alcohol consumption among alcoholics receiving the 5-HT3 antagonist ondansetron. In this study, they explored additional markers of ondansetron treatment response in alcoholics by examining polymorphisms in the
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Advice options you may Have (Caroline Bronte)

Some people may not realize that when it comes to seek out help and guidance through the advice that there are various possibilities. Each person is different, and a kind of guide option may not be the best choice for every person who should help through counseling. Some of the options that you may have when it comes to seeking out advice includes face to face counseling, online counseling and phone counseling. Each type has its own advantages, so it is important for you to decide which best meets your needs.

Face to face advice can you meet with your advisor in his or her Office. It gives the opportunity to get personal interaction and the ability to discuss your ideas, problems or questions directly to another person. Some people prefer this method because it provides personal interaction with the counselor. For some people, it is beneficial to be able to see the person they are talking to. You can still expect your session to be confidential, and you can get the added benefit of knowing your advisor in person.

If go to a counselor office puts you a little on the edge, maybe you'll have the opportunity to complete the online advice. Some advisers may offer certain sessions through chat, but others might prefer a more Visual method which uses a video to still complete meeting face to face. You still get the benefit of meeting with your advisor face to face, but you can do it from the comfort of your own home.


Telephone counseling has some of the same benefits as online advice. If you wish, you can fill in the session from the comfort of your own home. If you happen to have a mobile phone, you may be able to make your session wherever you choose –-even a place outside. Phone advice gives a certain freedom, but also a certain degree of anonymity in that your Advisor does not have to see your face and you don't need to go into your adviser Office if you do not want to.

There are actually a few different types of counseling settings, which you may have if you are looking for help. Some advisors will offer free sessions for you to get an idea whether that Adviser is right for you. You may also be able to try out a counseling method to view, if you prefer it. some of these methods include face-to-face counseling, online counseling and phone counseling. One method works not necessarily for each person; so don't be afraid to choose what can you best in the end.

Treatment ...
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Early Fetal Binge Alcohol Exposure Predicts High Behavioral Symptom Scores in 5.5-Year-Old Children









Fetal binge alcohol exposure has been associated with neurobehavioral and cognitive symptoms. This study explored whether binge drinking mainly before recognition of pregnancy predicted high symptom scores on the Strengths and Difficulties Questionnaire (SDQ) in 5.5-year-old children.



In a population-based, longitudinal study representative of pregnant women in Oslo, Norway,
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Alcohol-Metabolizing Genes and Alcohol Phenotypes in an Israeli Household Sample






Alcohol dehydrogenase 1B and 1C (ADH1B and ADH1C) variants have been robustly associated with alcohol phenotypes in East Asian populations, but less so in non-Asian populations where prevalence of the most protective ADH1B allele is low. Further, the joint effects of ADH1B and ADH1C on alcohol phenotypes have been unclear. Therefore, we tested the independent and joint effects of ADH1B and
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Lifetime and Current Mood and Anxiety Disorders in Short-Term and Long-Term Abstinent Alcoholics






A high prevalence of comorbid mood and anxiety disorders has been demonstrated in alcoholics. We examined lifetime and current mood and anxiety diagnoses and symptoms in long-term (mean 7.6 years; n = 110) and short-term (mean 10.1 weeks; n = 101) abstinent alcoholics (LTAA and STAA) and nonsubstance abusing controls (NSAC; n = 82). All alcoholics met DSM-IV lifetime alcohol dependence
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Activation of AMPK/TSC2/PLD by Alcohol Regulates mTORC1 and mTORC2 Assembly in C2C12 Myocytes






Ethanol (EtOH) decreases muscle protein synthesis, and this is associated with reduced mammalian target of rapamycin complex (mTORC)1 and increased mTORC2 activities. In contrast, phospholipase D (PLD) and its metabolite phosphatidic acid (PA) positively regulate mTORC1 signaling, whereas their role in mTORC2 function is less well defined. Herein, we examine the role that PLD and PA play in
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Risky Drinking, Risky Sex: A National Study of New Zealand University Students






Sexual risk taking and heavy alcohol use coexist in many populations of young people. A better understanding of the role of alcohol in sexual behaviors with health risks will inform preventive strategies. This study aimed to estimate the associations of risky sexual behavior with usual drinking pattern, with beliefs that alcohol will positively affect sexual experiences, and with drinking at
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Dimensions of Parental Alcohol Use/Problems and Offspring Temperament, Externalizing Behaviors, and Alcohol Use/Problems






Alcohol consumption (AC) and alcohol problems (AP) are complex traits. How many factors reflecting parental AC and AP are present in the large prospectively followed Avon Longitudinal Study of Parents and Children cohort? Would these factors be uniquely associated with various temperamental and alcohol-related outcomes in the children?



We factor-analyzed multiple items reflecting
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Effects of Family History of Alcohol Dependence on the Subjective Response to Alcohol Using the Intravenous Alcohol Clamp






Alcohol use disorders are well recognized to be common, debilitating, and the risk of developing them is influenced by family history (FH). The subjective response to alcohol may be determined familialy and related to the risk of developing alcoholism. The aim of this study was to evaluate differences between family history positive (FHP) and family history negative (FHN) individuals in
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The Patterns of Drug and Alcohol Use and Associated Problems Over 30 Years in 397 Men






Alcohol and drug use disorders (AUDs and SUDs) and their combination are relatively common and often occur together. However, the relationships of potential early life correlates of alcohol and drug disorders to the combined diagnoses have rarely been evaluated in long-term prospective studies or in populations at high risk of one of these diagnoses but not the other.



Data were analyzed
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Simple Ways to Get Out of Unhealthy Habits (Drugteststrips)

Many people today are suffering from unhealthy habits such as smoking, alcohol or illegal substance abuse. Unhealthy habits often result in health related issues. They can also negatively impact professional, social and economic well-being of an individual. Being aware of the harmful effects of unhealthy habits, many people are continuing with them assuming that getting out of these habits is very difficult. Some even think that it is impossible. In this article, we have mentioned some simple tips to help them come out of the unhealthy habits.

Do you want to change your unhealthy habit?:
If your answer is 'yes', then you can easily come out of unhealthy habits! It's true! The desire to break your bad habits itself is the primary step to achieve it. There are many people who do not even think of stopping these habits in spite of being aware of their harmful effects. You are at least better than that kind of people. But, don't just limit it to imagination. Make a proper planning and employ right measures to make your wish come true.

Take a firm decision:
A strong decision to quit bad habits can bring a positive change in your life. It is very difficult to achieve success if you don't have commitment. So, make firm determination to get out of substance abuse. Take it as a challenge and define specific goals to achieve success in a step-wise process. Practice healthy habits in your daily routine to detach yourself from unhealthy habits.

Stay away from substance abusing friends:
You may encounter many obstacles in the process of quitting unhealthy habits. It will be very difficult for you to break these habits in the company of substance abusing friends. It is better to avoid them. Simply reject any invitations from them and be bold to make them know that you are not interested in those habits.


Spend more time with family:
Emotional support from your family can help you get rid of drug or alcohol abusing habits. Instead of going out with your drug abusing friends, go for a walk or an outing with your family members. Get involved in family-related responsibilities, functions or activities.

One of the common reasons for drug abuse in many individuals is stress. Abusing drugs in order to reduce stress aggravates the situation. Individual may suffer from compound effects of stress and substance abuse. Therefore, this unhealthy habit of managing stress should be replaced with healthy options. You can have a simple and open chat with your family members. Share your feelings on substance abuse and accept their suggestions to give up the habit.

See the positive side of life:
Look at the benefits of healthy lifestyle. Inculcate healthy habits like regular exercise. Include nutritional food in your diet. They are known to reduce the risk of serious health issues like heart attacks and cancer.

Breaking unhealthy habits like substance abuse is possible. In fact, you can successfully get rid of unhealthy habits with the help of the above mentioned tips. So, be prepared to enjoy your healthy life by quitting unhealthy habits.

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The Role of Sociodemographic Factors in the Risk of Transition from Alcohol Use to Disorders and Remission in Singapore



The aim of the study was to define predictors of transition from alcohol use to disorders, and their remission, among adults residing in Singapore. The Singapore Mental Health Study was a cross-sectional survey conducted from December 2009 to December 2010. Information on alcohol use, regular use, DSM-IV criteria for abuse and dependence, and remission
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Proteomic Approaches for Studying Alcoholism and Alcohol-Induced Organ Damage





Proteomics research is concerned with the analysis of all proteins found in an organism, tissue, cell type, or cellular structure. The shotgun proteomic approach, which involves two-dimensional gel electrophoresis or liquid chromatography combined with mass spectrometry (MS), is used to identify novel proteins affected by alcohol. More targeted analyses study protein–protein interactions
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Global Actions: Commitments to Reduce Harmful Drinking - Aug 1 2013


Global Actions in Focus

Progress in Colombia initiatives



On July 29, 2013, Global Actions hosted a meeting in Bogotá, Colombia with Commitments signatory companies Bavaria/SABMiller, Pernod Ricard, and Diageo to assess and evaluate Colombia’s ongoing projects, challenges and future plans. Participants also discussed transitioning the programs to local sustainability.





Representatives
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Making the Case: Tools for Supporting Local Alcohol Policy in Ontario





Alcohol-related harms are often experienced at a local level, directly affecting communities, roadways and neighbourhoods. Local alcohol policies can be an important and effective way to promote moderate alcohol consumption, support community values, raise awareness of harms, influence community social norms and promote healthier communities (Government of British Columbia, 2012). Babor et
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Easy Steps to Get Rid of Depression

Depression is a very common disease of men and women of this fast moving world. Everything is changing rapidly. There are people who are not well equipped with the certain changes of this world. Nowadays we are going through a high competitive market. Everybody is busy with his own survival strategy. So as a result of this fact people are getting busy to their work. Most of the people fail to bring out spare time or leisure time for themselves. So it is quite obvious for them to get frustrated.

Depression comes from frustration. Depression comes from certain emptiness and incompleteness. If anybody gets depressed, then his entire life might have to face a worse result.

Here in this article we re going to discuss some natural ways to prevent this disease. You just go through these points.

Rise Early:

Rise early in the morning and you can feel the certain peace of the world that you cannot feel in the busy hours. In the first hour of the day everything remains fresh. It is the perfect time that you can give to yourself. Doctors say that between 3 am and the afternoon a hormone of human body alerts the other hormones. It mainly activates the other organs. It will be easier to you to get back to the work from this stage. It helps you to go back to the work gradually. You can scatter the work pressure to some parts of the day. Now if you want to get rid of the depression and anxiety then you must have to wakeup enough early in the morning. You should wake up in the dawn.

Find out the Root:

You should have to find out the root that causes the depression. If you are able to stress it out then you should avoid this very carefully. Otherwise you will have to face this problem in your later life. So it is up to you how you can handle this problem.

Live Your Passion:

Yon should spend as much time as you can in which you have a passion. Do the job which you like and avoid those which are the causes behind your depression. These types of works can give you mental pleasure that is very much effective to cure the problem of depression.

Breathing Exercise:

Breathing is an exercise. You should breathe properly. You should take long ad deep and breathe. It helps to make clear the lungs. But make it a point that you will practice this very slowly. This is also a very good process to get rid of you depression.

You can get rid of depression if you take Generic Abilify. This is a very much effective medicine to prevent this problem. In this article we have also got some necessary information regarding this disease. These above mentioned points will surely help you to cure this disease. The main thing is the mental balance. Mental imbalance causes this type of disease. If you want to get cured quickly then you will have to follow these above mentioned instructions.

Andrew Greens, a well-known author writes articles on health and drug related issues. In this article Andrew has written on depression which can be cured with the help of Generic Abilify . She writes for http://www.blueskydrugs.com
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