Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake

Compulsive drinking despite serious adverse medical, social and economic consequences is a characteristic of alcohol use disorders in humans. Although frontal cortical areas have been implicated in alcohol use disorders, little is known about the molecular mechanisms and pathways that sustain aversion-resistant intake.

Here, we show that nucleus accumbens core (NAcore) NMDA-type glutamate