Genetic and Neurophysiological Correlates of the Age of Onset of Alcohol Use Disorders in Adolescents and Young Adults

Discrete time survival analysis was used to assess the age-specific association of event-related oscillations (EROs) and CHRM2 gene variants on the onset of regular alcohol use and alcohol dependence.
The subjects were 2,938 adolescents and young adults ages 12–25.

Results showed that the CHRM2 gene variants and ERO risk factors had hazards which varied considerably with age. The bulk of the