Characterization of Functional Polymorphisms and Glucocorticoid-Responsive Elements in the Promoter of TDO2, a Candidate Gene for Ethanol-Induced Behavioural Disorders

In response to acute ethanol consumption, tryptophan 2,3-dioxygenase (TDO) induces the kynurenine pathway (KP) through a glucocorticoid-mediated mechanism, which could lead to a dramatic accumulation of neurotoxic metabolites in association with serotonin depletion. As a result, interindividual variability in ethanol-induced behavioural disorders, such