The molecular features of tongue epithelium treated with the carcinogen 4-nitroquinoline-1-oxide (4-NQO) and alcohol as a model for HNSCC.

Cancer of the head and neck (HNSCC) is the sixth most common type of cancer affecting humans worldwide. To determine the potential mechanisms by which chronic tobacco and alcohol abuse lead to HNSCC of the oral cavity, we have used both the 4-nitroquinoline-1-oxide (4-NQO) murine oral carcinogenesis and the Meadows-Cook alcohol models.
In this study, we